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Thomas R. Kelly, MD

AMA Arch Surg. 1970;101(2):193-199.

Abstract
Endogenous hyperparathyroidism was produced in inbred rats and the effect on gastric acid and mucus secretion and mucosal ulceration studied. There was no alteration in gastric acidity except during the period of marked hypercalcemia, when it was slightly decreased. Gastric mucus secretion decreased in 73% of the rats. Twenty-seven percent of the animals developed mucosal ulcerations. In the absence of gastric hypersecretion, it is suggested that decrease in mucus secretion may play a role in the defense mechanism against peptic ulceration in association with hyperparathyroidism.

Author Affiliations
Akron, Ohio

From the Surgical Research Department of Akron City Hospital, Akron, Ohio.

Footnotes
Accepted for publication April 9, 1970.

Read before the 27th annual meeting of the Central Surgical Association, Detroit, Feb 27, 1970.

Reprint requests to Akron City Hospital, 550 East Market St, Akron, Ohio 44304 (Dr. Kelly).

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