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The Effect of Atropine

John S. Crispin, MD, FRCSC, FACS; Yuen W. Choi, MD; David G. H. Wiseman, MD; Duncan J. Gillespie, MD, FRCSC; James F. Lind, MD, CM, FRCSC, FACS

AMA Arch Surg. 1970;101(2):215-218.

Abstract
A technique has been developed for repeated, direct, manometric study of the canine choledochoduodenal junction in conscious animals. The junction is characterized by a zone of elevated pressure interposed between the duodenum and common bile duct whose motor activity distinguishes it from these adjacent structures. Atropine sulfate administration resulted in a decrease in pressure in the junctional zone suggesting that a cholinergic mechanism is partly responsible for the maintenance of resting pressure in the canine choledochoduodenal junction.

Author Affiliations
Winnipeg, Manitoba, Canada

From the Department of Surgery, University of Manitoba and the Gastroenterology Section of the Clinical Investigation Unit, Winnipeg General Hospital, Winnipeg, Manitoba, Canada.

Footnotes
Accepted for publication April 15, 1970.

Read before the 27th annual meeting of the Central Surgical Association, Detroit, Feb 27, 1970.

Reprint requests to Department of Surgery, Winnipeg General Hospital, Winnipeg 3, Manitoba, Canada (Dr. Crispin).

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