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Robert H. Resnick, MD; Thomas C. Chalmers, MD; Guru P. Chatterjee, MD; Morton M. Madoff, MD

AMA Arch Surg. 1970;101(3):353-358.

Abstract
Impairment of glomerular filtration rate (GFR), renal plasma flow (RPF), and maximal urinary concentrating capacity was noted in the surgical and medical survivors of a controlled study of colon bypass. Statistically similar, but slightly higher mean values for GFR and RPF were observed in nonedematous, nonencephalopathic cirrhotic patients who had recently recovered from a bout of hepatic decompensation. Patient selection is considered to be the most significant factor in explaining these clinical observations which differ from earlier published reports. The experimental findings did not support the concept of renal injury causally related to chronic use of neomycin sulfate or protein restriction. Clinical improvement in hepatic encephalopathy following colon bypass was unrelated quantitatively or qualitatively to the intestinal microflora.

Author Affiliations
Boston

From the Gastrointestinal Research Unit of the Medical Services, Lemuel Shattuck Hospital; Department of Public Health, Commonwealth of Massachusetts; and the departments of medicine and physiology, Tufts University Medical School, Boston.

Footnotes
Accepted for publication April 15, 1970.

Reprint requests to Boston Inter-Hospital Liver Group, Lemuel Shattuck Hospital, 170 Morton St, Boston 02130 (Dr. Resnick).

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