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Following Hemorrhagic and Endotoxic Shock in the Dog

Michael G. Bower, MD; Sadaaki Okude, MD; Weldon B. Jolley, PhD; Louis L. Smith, MD

AMA Arch Surg. 1970;101(3):411-415.

Abstract
The circulatory effects of glucagon were studied in hemorrhagic and endotoxic shock. Glucagon administration had several significant effects—increase in cardiac output, decrease in arterial pressure, decrease in peripheral resistance, increase in heart rate, increase in stroke volume following hemorrhage but not after endotoxin administration, and a tendency to increase central venous pressure. From this study, it appears that glucagon is a beneficial agent in improving the cardiovascular status of experimental animals subjected to hemorrhagic and endotoxic shock.

Author Affiliations
Loma Linda, Calif

From the Surgical Research Laboratory, Loma Linda University School of Medicine, Loma Linda, Calif.

Footnotes
Accepted for publication March 10, 1970.

Read before the sectional meeting of the Southern California Chapter of the American College of Surgeons, Coronado, Calif, Jan 16, 1970.

Reprint requests to Surgical Research Laboratory, Loma Linda University, Loma Linda, Calif 92354 (Dr. Smith).

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ABSTRACT