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Infusion of Cell-Free Fluids Into Rabbits in Hemorrhagic ShockI. Study in Survival With Chemically Defined Fluids
Mark W. Wolcott, MD;
Theodore I. Malinin, MD
AMA Arch Surg. 1970;101(4):513-515.
Abstract
Four cell-free solutions were evaluated in the treatment of hemorrhagic shock in a rabbit shock model. The solutions used consisted of two colloid solutions; glutamyl polypeptide (GPP) and dextran 40 (low molecular weight dextran); and two crystalloid solutions: lactated Ringer's solution and Hank's balanced salt solution (HBSS) mixed with equal parts of saline. The polyglutamic acid, GPP in the concentration used, proved to be considerably more effective, as measured by animal survival, than either of the other three.
Author Affiliations
Washington, DC; Washington, DC, and Rockville, Md
From the Research Service, Veterans Administration and George Washington University, Washington, DC (Dr. Wolcott) and the Biomedical Research Institute, American Foundation for Biological Research, Rockville, Md, and the Department of Research Pathology, Georgetown Medical School, Washington, DC (Dr. Malinin). Dr. Wolcott is now at the Veterans Administration Hosptial and the University of Utah School of Medicine, Salt Lake City. Dr. Malinin is now at the University of Miami School of Medicine, Miami, Fla.
Footnotes
Accepted for publication June 9, 1970.
Reprint requests to Veterans Administration Hospital, 500 Foothill Dr, Salt Lake City 84113 (Dr. Wolcott).
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Infusion of Cell-Free Fluids Into Rabbits in Hemorrhagic Shock: Replacement of Blood With Crystalloid Fluids of Various Tonicities
Malinin and Wolcott
Arch Surg 1973;106:86-89.
ABSTRACT
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