This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citing articles on HighWire  • Citing articles on Web of Science (22)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

By Pancreatic Duct Ligation

Leon Morgenstern, MD; C. Snyder Patin; Harry L. Krohn, MD; Nathan Hiatt, MD

AMA Arch Surg. 1970;101(5):586-589.

Abstract
Prior pancreatic ductal ligation is a simple and effective experimental method for prolonging survival after a lethal dose of abdominal X-irradiation in dogs. In contrast to the usual average survival time of four days in lethally irradiated controls, survival times up to 153 days were achieved in animals with prior pancreatic ductal ligation. In 13 animals, the average survival time was 38 days. It is theorized that neutralization of intraintestinal proteolytic enzymes to decrease mucosal damage may prove useful clinically in enteropathies of varying etiological patterns.

Author Affiliations
Los Angeles

From the Department of Surgery, Medical Research Institute, Cedars-Sinai Medical Center, Los Angeles.

Footnotes
Accepted for publication March 3, 1970.

Read before the sectional meeting of the Southern California Chapter of the American College of Surgeons, Coronado, Calif, Jan 16, 1970.

Reprint requests to 4833 Fountain Ave, Los Angeles 90029 (Dr. Morgenstern).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Influence of Short-Term Octreotide Administration on Chronic Tissue Injury, Transforming Growth Factor {beta} (TGF-{beta}) Overexpression, and Collagen Accumulation in Irradiated Rat Intestine
Wang et al.
J. Pharmacol. Exp. Ther. 2001;297:35-42.
ABSTRACT | FULL TEXT  

Elemental Diet as Prophylaxis Against Radiation Injury: Histological and Ultrastructural Studies
McArdle et al.
Arch Surg 1985;120:1026-1032.
ABSTRACT