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Louie C. Wilson, MD; Benson R. Wilcox, MD; Winfred L. Sugg, MD; Richard M. Peters, MD

AMA Arch Surg. 1970;101(6):756-759.

Abstract
From June 1966 to December 1969, 11 prosthetic valves were inserted in ten patients at North Carolina Memorial Hospital because of valvular regurgitation complicating active infective endocarditis. Indications for operation included intractable heart failure, resistant infection, and repeated embolization. Operative mortality was 40%. One patient died 2 years following operation from unrelated causes. The five survivors, 20 months to four vears following operation, are well and leading active lives. The predominant organisms were streptococcus and staphylococcus. Two of three patients with positive blood cultures one day prior to surgery and four of six patients with organisms demonstrated microscopically at operation are alive and free of recurrent infection for as long as 3 years. This experience demonstrates that valve replacement is possible in the active phase of endocarditis if adequate antibiotic coverage is used and the focus of infection removed.

Author Affiliations
Chapel Hill, NC

From the Division of Cardiovascular and Thoracic Surgery, School of Medicine, University of North Carolina, Chapel Hill, NC.

Footnotes
Accepted for publication Aug 6, 1970.

Read before the 18th scientific meeting of the International Cardiovascular Society, Chicago, June 20. 1970.

Reprint requests to Division of Cardiovascular and Thoracic Surgery, School of Medicine, University of North Carolina, Chapel Hill, NC 27514 (Dr. Wilson).

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