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From the Small Intestine of Dogs Following Endotoxin Shock

Anne M. Ambromovage, PhD; Umakant Shah, MD; John M. Howard, MD

AMA Arch Surg. 1971;102(5):496-500.

Abstract
It has been noted by a number of investigators that the irreversibility of shock probably results from the escape of endotoxin from the lumen of the small bowel into the circulation. In order to test this concept, studies in dogs with isolated jejunal loops were done to compare the absorption of xylose, a normally absorbed sugar, with that of inulin, a polysaccharide not normally absorbed. Experiments were performed in the normal animal, as well as during reversible and irreversible shock. The results indicate that in the presence of severe hypotension, permeation of the mucosa by inulin (molecular weight, 5,000) is increased. This is associated with a decreased absorption of xylose.

Author Affiliations
Philadelphia

From the Department of Physiology and Biophysics (Dr. Ambromovage) and Department of Surgery (Drs. Shah and Howard), Hahnemann Medical College and Hospital, Philadelphia.

Footnotes
Accepted for publication Jan 25, 1971.

Reprint requests to Hahnemann Medical College, 235 N 15th St, Philadelphia 19102 (Dr. Ambromovage).

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