This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citing articles on HighWire  • Citing articles on Web of Science (3)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Peter A. Banks, MD; Peter T. Sum, MD

AMA Arch Surg. 1971;102(5):505-508.

Abstract
In unanesthetized dogs with chronic gastric and pancreatic fistulas, an intravenous infusion of acetazolamide (Diamox), superimposed on a steady-state infusion of secretin, caused a prompt reduction in the volume and bicarbonate concentration of pancreatic secretion and a delayed reduction in potassium concentration. These changes were not caused by alterations in serum electrolytes or by the development of a metabolic acidosis. The reductions in volume and bicarbonate concentration were too rapid and extensive to be accounted for by compensatory respiratory mechanisms, and hence reflect a direct effect of acetazolamide on pancreatic secretion. Reductions in bicarbonate concentration during the infusion of acetazolamide appeared to bear a physiologic relationship to the induced slower flow rates.

Author Affiliations
Boston

From the departments of surgery (Dr. Sum) and gastroenterology (Dr. Banks), Beth Israel Hospital and Harvard Medical School, Boston.

Footnotes
Accepted for publication Dec 21, 1970.

Reprint requests to 1101 Beacon St, Brookline, Mass 02146 (Dr. Banks).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

The stoichiometry of the electrogenic sodium bicarbonate cotransporter pNBC1 in mouse pancreatic duct cells is 2 HCO3-:1 Na+
Gross et al.
J. Physiol. 2001;531:375-382.
ABSTRACT | FULL TEXT  

Expression and distribution of the Na+-HCO-3 cotransporter in human pancreas
Marino et al.
Am. J. Physiol. Gastrointest. Liver Physiol. 1999;277:G487-G494.
ABSTRACT | FULL TEXT