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Douglas W. Wilmore, MD; John M. Daly; Stanley J. Dudrick, MD; Harry M. Vars, PhD

AMA Arch Surg. 1971;102(5):509-511.

Abstract
Ten adult beagles with vagally denervated fundic pouches ate a standard kennel diet while fluid requirements were satisfied by the intravenous administration of parenteral solutions infused continuously 24 hr/day. Solutions studied were 5% dextrose in water and 5% dextrose in 0.9% saline, administered in volumes equal to or twice the average daily oral water intake. Gastric secretory output and acid concentration decreased an average of 22% with the intravenous administration of daily fluid requirements. While infusing dextrose in saline, gastric volume and acid output increased an average of 33% when compared with the period of parenteral water administration. Increasing the parenterally administered salt or water solutions by twice the volume resulted in no change in pouch output, acid secretion, or electrolyte concentration.

Author Affiliations
Philadelphia

From the Harrison Department of Surgical Research and the Department of Surgery School of Medicine, University of Pennsylvania, Philadelphia.

Footnotes
Accepted for publication Dec 30, 1970.

Reprint requests to 3400 Spruce St, Philadelphia 19104 (Dr. Wilmore).

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