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Comparative Hemodynamic Effects

Taylor I. Cook, MD; Cleve Trimble, MD; David E. Smith, MD; Irving Rehman, PhD; Max J. Trummer, MD

AMA Arch Surg. 1971;102(6):586-588.

Abstract
A comparative analysis of the cardiopulmonary effects of intermittent positive pressure breathing (IPPB) and extrathoracic assisted breathing (ETAB) has been performed in closed-chest anesthetized animals subjected to sublethal acute hemorrhage. Equal inspiratory times and rates were maintained at high tidal volumes with a prolonged inspiratory phase. Significant suppression of cardiac output occurred in all trials, with slightly less suppression accompanying ETAB. Respiratory phase analysis of central venous and pulmonary arterial pressures suggests that impedance to transpulmonary blood flow occurred with IPPB primarily during inspiration and with ETAB during expiration, although of lesser degree. The greater interference of IPPB with cardiac output was largely due to its detrimental phase being twice as long as that of ETAB.

Author Affiliations
San Diego, Calif

From the Shock Research Unit, Naval Hospital, San Diego, Calif.

Footnotes
Accepted for publication Feb 10, 1971.

Read before the annual meeting of the Southern California Chapter of the American College of Surgeons, Palm Springs, Calif, Jan 16, 1971.

The opinions or assertions contained herein are those of the authors and are not to be construed as official or as reflecting the views of the Navy Department.

Reprint requests to Shock Research Unit, Naval Hospital, Park Avenue, San Diego, Calif 92134 (Dr. Cook).

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