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Alan Marty, MD; LCDR Cleve Trimble, MC, USNR; LCDR Taylor Cook, MC, USN; Max Trummer, MD; Benjamin W. Zweifach, PhD; Marcos Intaglietta, PhD

AMA Arch Surg. 1971;103(1):48-50.

Abstract
Preliminary to assigning significance to therapeutically induced changes in plasma colloid osmotic pressure (COP), it is necessary to know how this parameter varies under controlled conditions such as absolute bed rest. Accordingly, the following data were obtained at eight-hour intervals from seven healthy subjects maintained supine for two separate 48-hour periods: plasma COP, alveolar-arterial oxygen pressure (Po₂) gradients, pulmonary shunt fractions, cardiac index, total peripheral resistance, and mean arterial blood pressure. Results indicated that with ambulation, oncotic pressure rose significantly. With recumbency, plasma COP varied considerably (± 10%), while the other data reflecting cardiopulmonary function remained normal. The extent of this variation of plasma COP in recumbent normal humans was the same range as the changes that others report effected by albumin and diuretic therapy.

Author Affiliations
San Diego, Calif

From the departments of bioengineering and surgery, University of California, and the Surgical Research Unit, US Naval Hospital, San Diego, Calif.

Footnotes
Accepted for publication Feb 26, 1971.

Read before the annual meeting of the Southern California Chapter of the American College of Surgeons, Palm Springs, Calif, Jan 15, 1971.

The opinions or assertions contained herein are those of the authors and are not to be construed as official or as reflecting the views of the Navy Department.

Reprint requests to Department of Surgery, Cedars of Lebanon Hospital, Los Angeles 90054 (Dr. Marty).

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