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Stuart D. Wilson, MD; William J. Schulte, MD; Robert C. Meade, MD

AMA Arch Surg. 1971;103(2):108-115.

Abstract
Fifteen children with islet-cell tumor (s) of the pancreas and ulcer diathesis (Zollinger-Ellison syndrome) were collected in a tumor registry established to study pathophysiology and natural history of this syndrome. Eight children had less than total gastrectomy and six of these died. Five died from complications of recurrent ulcerations. All seven children with total gastrectomy remain alive and well. Metastatic or multiple tumors or both were present in all seven at the time of total gastrectomy. Follow-up bioassay or gastrin radioimmunoassay studies were performed in six of the seven patients. Serum gastrin levels remained elevated for periods of 5 and 11 years in two patients. Presumably gastrin-producing tumor remains in those patients. One patient with increased gastrin six years after total gastric resection now has low levels after eight years. Two other patients have progressively lower levels each year following total gastrectomy.

Author Affiliations
Milwaukee

From the Division of Surgery, Medical College of Wisconsin; Radioisotope Service, Wood Veterans Hospital Center; and the Allen-Bradley Medical Science Laboratory, Milwaukee.

Footnotes
Accepted for publication April 12, 1971.

Read before the 28th annual meeting of the Central Surgical Association, Minneapolis, March 4, 1971.

Reprint requests to 8700 W Wisconsin Ave, Milwaukee 53226 (Dr. Wilson).

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