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Frederick A. Reichle, MD; David L. Newcomer; M. Prince Brigham, MD; Rose Marie Reichle; Linda Labinsky; George P. Rosemond, MD

AMA Arch Surg. 1971;103(2):133-139.

Abstract
The histamine concentration of duodenum and jejunum in rats is lower following vagotomy with gastrectomy or pyloroplasty than after gastrectomy or pyloroplasty alone. These changes may relate to known alterations in postvagotomy gastrointestinal motility. A lack of alteration in postvagotomy gastric histamine concentration has been confirmed and does not support a role of histamine in decreased gastric acid secretion following vagotomy. Whereas serotonin concentration of the proximal small intestine is decreased by loss of pyloric sphincter mechanism with or without vagotomy, histamine concentrations appear dependent on vagal integrity.

Author Affiliations
Philadelphia

From the Department of Surgery, Temple University Health Sciences Center, Philadelphia.

Footnotes
Accepted for publication March 17, 1971.

Read before the 28th annual meeting of the Central Surgical Association, Minneapolis, March 4, 1971.

Reprint requests to 3401 N Broad St, Philadelphia 19140 (Dr. Reichle).

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