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A Morphological and Metabolic Approach to the Stress Ulcer Problem

Chu-Jeng Chiu, MD, PhD; A. Hope McArdle, PhD; Rea A. Brown, MD; Henry J. Scott, MD; Fraser N. Gurd

AMA Arch Surg. 1971;103(2):147-152.

Abstract
Following approximately 40% body surface scalding, the rats were fasted for 24 hours. Compared with that of a control group, the gastric mucosa of the scalded animals contained significantly less adenosine triphosphate (ATP), and the ability of the mucosal cells to consume oxygen in vitro was also impaired. Morphological study of the early damage to the gastric mucosal epithelium in these animals as well as in other species revealed separation of the cells, often as a strip, subsequent to the development of a space at the infranuclear portion. The underlying microvessels were congested. The similarity between such metabolic and morphological changes to those observed in ischemic intestinal mucosa is discussed. It is suggested that such changes taking place in the mucosal cells, which represent the gastric barrier against the hostile intraluminal content, are an important process which may lead to the development of stress ulcer in the stomach.

Author Affiliations
Montreal

From the McGill University Surgical Clinic, Montreal General Hospital.

Footnotes
Accepted for publication March 17, 1971.

Read before the 28th annual meeting of the Central Surgical Association, Minneapolis, March 4, 1971.

Reprint requests to McGill University Surgical Clinic, Montreal General Hospital, 1950 Cedar Ave, Montreal 109, PQ (Dr. Chiu).

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