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Effect on Experimental Renal Hypertension

Carl Manz, MD; Yoshio Sako, MD

AMA Arch Surg. 1971;103(2):242-247.

Abstract
The effect of the splenic artery implanted in the renal cortex was observed in a group of 20 normal dogs and 20 dogs made hypertensive by renal artery constriction and contralateral nephrectomy. Observations were made by measuring renal function, blood pressure, blood flow, selective angiography, ligation of the splenic artery implant or of the renal artery, and by postmortem examination. Hypertensive control dogs formed part of the study and the observations were made over a period of two years. The study showed that the splenic artery usually stays open, forms communication with the renal artery, relieves hypertension, and may serve effectively as the only source of renal arterial supply. Implant patency is more frequent in the ischemic kidney, but in some instances patency and high flow may occur without relief of hypertension because an arteriovenous fistula has formed.

Author Affiliations
Minneapolis

From the Department of Surgery, University of Minnesota, and the Surgical Service, Veterans Administration Hospital, Minneapolis.

Footnotes
Accepted for publication March 22, 1971.

Read before the 28th annual meeting of the Central Surgical Association, Minneapolis, March 5, 1971.

Reprint requests to Surgical Service, Veterans Administration Hospital, 48th Avenue and 54th Street, Minneapolis 55417 (Dr. Manz).

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