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Wilhelm Kreuzer, MD; Worthington G. Schenk, Jr., MD

AMA Arch Surg. 1971;103(2):277-282.

Abstract
The effect of two intra-arterially injected vasodilating agents on the oxygen uptake of tissue and on blood flow through a critical stenosis has been investigated in the dog. Blood flow increase always occurred through the stenotic segment, but this change was small. Concomitant with this small flow increase the oxygen consumption of the tissue distal to the stenosis was found to be significantly decreased by the vasodilator infusion. This decreased oxygen consumption was manifested by marked narrowing of the arteriovenous oxyhemoglobin difference, suggesting that the agents infused opened arteriovenous shunts.

Author Affiliations
Buffalo

From the Department of Surgery, State University of New York at Buffalo and the Surgical Research Laboratories, Edward J. Meyer Memorial Hospital, Buffalo.

Footnotes
Accepted for publication March 31, 1971.

Read before the 28th annual meeting of the Central Surgical Association, Minneapolis, March 5, 1971.

Reprint requests to Department of Surgery, 462 Grider St, Buffalo 14215 (Dr. Kreuzer).

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