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Electrophysiological Basis for Supraventricular ArrhythmiasFollowing Surgical Procedures for Aortic Stenosis
Harry L. Bush, Jr., MD;
Henry Gelband, MD;
Brian F. Hoffman, MD;
James R. Malm, MD
AMA Arch Surg. 1971;103(5):620-625.
Abstract
Fifty-eight patients with isolated aortic stenosis who underwent open heart surgery during a three-year period had a 49% incidence of postoperative supraventricular arrhythmias (SVAs). Of the 22 patients under 20 years of age (group A), four (18%) had postoperative SVAs, in contrast to 24 of the 36 patients (66.7%) over 40 years of age (group B). The increase in SVAs in group B was due to increased frequency of atrial flutter-fibrillation. The electrophysiologic characteristics of the right atrial myocardium were normal in group A, but were markedly abnormal in group B. The diffuse spontaneous phase-4 depolarization, local conduction disturbances, and abnormal transmembrane action potential characteristics found in group B could result in multifocal ectopic pacemakers and reentry arrhythmias. Therefore, the majority of the postoperative SVAs in group B may be related to the preoperative cellular abnormalities of their right atrial myocardium.
Author Affiliations
New York
From the Department of Surgery, College of Physicians and Surgeons, Columbia University; and the Surgical Service, Presbyterian Hospital, New York (Drs. Bush and Malm); and the Department of Pharmacology, Columbia University, New York (Drs. Gelband and Hoffman). Dr. Bush is now with the US Naval Hospital, Patuxent River, Md.
Footnotes
Accepted for publication July 6, 1971.
Read before the 19th scientific meeting of the International Cardiovascular Society, Philadelphia, June 18, 1971.
Reprint requests to 622 W 168th St, New York 10032 (Dr. Malm).
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