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Murray F. Brennan, BM, FRACS; Ruary C. O'Connell, MB, BCh, BAO; Jo Ann Rosol; Ruth Kundsin, DSc

AMA Arch Surg. 1971;103(6):705-708.

Abstract
The ability of Candida albicans (American type culture collection 10231) a known human pathogen, to grow in various amino acid and dextrose mixtures available for human parenteral nutrition was investigated in vitro by colony counts, generation times, and growth curve analysis. Growth of this pathogen occurred rapidly in all mixtures at 30 and 37 C, was inhibited by cooling to 4 C. Growth was greater in solutions containing amino acids, dextrose, and electrolytes than it was in dextrose, or amino acids, or amino acid with electrolytes alone. Growth varied to the quantity of the constituent amino acids. Thus cooling should be an essential feature of storage and the actual content of these mixtures should be a consideration before embarking on therapy.

Author Affiliations
Boston

From the Department of Surgery, Harvard Medical School at the Peter Bent Brigham Hospital, Boston.

Footnotes
Accepted for publication Aug 23, 1971.

Reprint requests to 721 Huntington Ave, Boston 02115 (Dr. Brennan).

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