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Christian D. Thorpe, MD; Charles F. Frey, MD

AMA Arch Surg. 1971;103(6):720-723.

Abstract
Unlike dog preparations, high pressure injection of bile and bile salt (taurocholate) does not cause immediate fatal pancreatitis in pigs. Bile salt does induce pseudocyst formation, pancreatic suppuration, septicemia, and azotemia in pigs. Pancreatic infusion of trypsin is also sublethal in pigs, but the combination of trypsin and bile salts at physiologic injection pressures produces a high mortality from acute hemorrhagic pancreatitis.

Author Affiliations
Ann Arbor, Mich

From the Section of General Surgery, Department of Surgery, University of Michigan Medical Center, Ann Arbor.

Footnotes
Accepted for publication March 15, 1971.

Reprint requests to Department of Surgery, University of Michigan Medical Center, 1405 E Ann St, Ann Arbor, Mich 48104 (Dr. Frey).

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