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Peter Cuevas, MD; Louis M. de la Maza, MD; John Gilbert, PhD; Jacob Fine, MD

AMA Arch Surg. 1972;104(3):319-322.

Abstract
Endotoxemia was demonstrated in over 90% (28 of 30) of a series of animals subjected to one of four different types of refractory shock. Microscopic study of the lungs showed that the changes characteristic of the lung lesion in shock did not occur unless an endotoxemia developed and persisted until death. When pretreatment by inducing resistance to endotoxin or by intraintestinal administration of nonabsorbable antibiotics prevented the endotoxemia or converted a persistent to a transient endotoxemia, there was a corresponding reduction in the incidence of the lung lesion and the mortality.

Author Affiliations
Boston; Cambridge, Mass; Boston

From the Fifth Harvard Surgical Service (Drs. Cuevas and Fine) and the Mallory Institute of Pathology (Dr. de la Maza), Boston City Hospital; and the Harvard Computer Center, Cambridge, Mass (Dr. Gilbert).

Footnotes
Accepted for publication July 26, 1971.

Reprint requests to 818 Harrison Ave, Boston 02118 (Dr. Fine).

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