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Lester R. Bryant, MD, DSc; David Preston, MD; J. Kent Trinkle, MD; John A. Koepke, MD

AMA Arch Surg. 1972;104(3):325-329.

Abstract
Sixty-five mongrel dogs were subjected to left lung allotransplantation with immunosuppression. Serial assessment of graft function and rejection was made by bronchospirometry, xenon Xe 133 and radioalbumin scintiscans, and open lung biopsy. Correlation of data shows (1) scintiscans should be performed at not more than 48-hour intervals during the first 21 days; (2) early rejection is suggested by a decrease in perfusion in the presence of a satisfactory topographical ventilation scan; and (3) late rejection is indicated by concomitant deterioration of perfusion and ventilation scans, but cannot be distinguished from progressive infection by scintiscan techniques.

Author Affiliations
Lexington, Ky

From the divisions of cardio-thoracic surgery (Drs. Bryant and Trinkle) and nuclear medicine (Dr. Preston) and Department of Pathology (Dr. Koepke), University of Kentucky Medical Center, Lexington.

Footnotes
Accepted for publication Aug 30, 1971.

Read before the Section on Diseases of the Chest at the 120th annual convention of the American Medical Association, Atlantic City, NJ, June 21, 1971.

Reprint requests to Department of Surgery, University of Kentucky Medical Center, 800 Rose St, Lexington, Ky 40506 (Dr. Bryant).

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