This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on Web of Science (297)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Ezra Steiger, MD; Harry M. Vars, PhD; Stanley J. Dudrick, MD

AMA Arch Surg. 1972;104(3):330-332.

Abstract
Equipment, techniques, and solutions have been developed for the chronic intravenous feeding of rats. With use of a special harness and fluid infusion swivel assembly, 140- to 250-gm, unrestrained rats can be fed for weeks at a time exclusively by vein, allowing for prolonged periods of metabolic and nutritional study. A 32% dextrose and 5% amino acid solution containing essential minerals and vitamins was formulated for the intravenous feeding regimen. This model can be readily utilized and has great potential value for studying problems related to surgical nutrition and metabolism.

Author Affiliations
Philadelphia

From the Harrison Department of Surgical Research (Dr. Vars) and the Department of Surgery (Drs. Steiger and Dudrick), University of Pennsylvania School of Medicine, and the Philadelphia Veterans Administration Hospital, Philadelphia.

Footnotes
Accepted for publication July 16, 1971.

Reprint requests to 3400 Spruce St, Philadelphia 19104 (Dr. Steiger).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Jonathan E. Rhoads Lecture: Experiences and Observations in the Management of Patients With Short Bowel Syndrome
Steiger
JPEN J Parenter Enteral Nutr 2007;31:326-333.
ABSTRACT | FULL TEXT  

IV Hypertonic Glucose Stimulates the Exocrine Pancreas in Rat
Fan and Andren-Sandberg
JPEN J Parenter Enteral Nutr 2006;30:40-44.
ABSTRACT | FULL TEXT  

Per2 Gene Expressions in the Suprachiasmatic Nucleus and Liver Differentially Respond to Nutrition Factors in Rats
Iwanaga et al.
JPEN J Parenter Enteral Nutr 2005;29:157-161.
ABSTRACT | FULL TEXT  

Quantitative evolutionary design of nutrient processing: Glucose
Steyermark et al.
Proc. Natl. Acad. Sci. USA 2002;99:8754-8759.
ABSTRACT | FULL TEXT  

The Accumulation and Energy Load of Exogenous Lipids in Cirrhotic Rat Liver After Partial Hepatectomy
Matsui et al.
JPEN J Parenter Enteral Nutr 1995;19:313-318.
ABSTRACT  

Effects of Total Parenteral Nutrition on Lipid Metabolism in Rats
Ekelund et al.
JPEN J Parenter Enteral Nutr 1994;18:503-509.
ABSTRACT  

Increased Energy Expenditure After Intravenous Administration of Amino Acids
Hayashida et al.
JPEN J Parenter Enteral Nutr 1992;16:142-148.
ABSTRACT  

Effect of Methionine-Deprived Nutrition on Cell Growth and Cell Kinetics in Cell Cultures and Experimental Tumors
Usami et al.
JPEN J Parenter Enteral Nutr 1991;15:540-545.
ABSTRACT  

Infusion of Enteral vs Parenteral Nutrients Using High-Concentration Branch-Chain Amino Acids: Effect on Wound Healing in the Postoperative Rat
Delany et al.
JPEN J Parenter Enteral Nutr 1991;15:464-468.
ABSTRACT  

Effect of Taurine on Total Parenteral Nutrition-Associated Cholestasis
Guertin et al.
JPEN J Parenter Enteral Nutr 1991;15:247-251.
ABSTRACT  

Effect of Various Lipid Emulsions on Total Parenteral Nutrition-Induced Hepatosteatosis in Rats
Nakagawa et al.
JPEN J Parenter Enteral Nutr 1991;15:137-143.
ABSTRACT  

Differential Effects of Parenteral Nutrition on Tumor Growth and Erythrocyte Polyamine Levels in the Rat
Grossie et al.
JPEN J Parenter Enteral Nutr 1989;13:590-595.
ABSTRACT  

Pentobarbital Improves Nitrogen Retention in Sepsis
Dickerson et al.
JPEN J Parenter Enteral Nutr 1989;13:359-361.
ABSTRACT  

In Vivo Biliary Function in the Adult Rat: The Effect of Parenteral Glucose and Amino Acids
Rivera et al.
JPEN J Parenter Enteral Nutr 1989;13:240-245.
ABSTRACT  

Imbalance between Jejunum and Ileum in the Response of Brush Border Hydrolases to Oral Feeding after Intravenous Alimentation in Rats
Galluser et al.
JPEN J Parenter Enteral Nutr 1989;13:37-40.
ABSTRACT  

Influence of Total Parenteral Nutrition on Tumor Growth and Polyamine Biosynthesis of Fibrosarcoma-Bearing Rats after Induced Cachexia
Grossie et al.
JPEN J Parenter Enteral Nutr 1988;12:441-444.
ABSTRACT  

Intestinal Maturation in the Rat: The Role of Enteral Nutrients
Castillo et al.
JPEN J Parenter Enteral Nutr 1988;12:490-495.
ABSTRACT  

Tissue Levels of Vitamin E ({alpha}-Tocopherol) in Response to Continuous Intravenous Multivitamin Infusion
Gutcher
JPEN J Parenter Enteral Nutr 1988;12:152-154.
ABSTRACT  

A New Apparatus for Chronic Intravenous Infusion in Unrestrained Rats
Takeyama et al.
JPEN J Parenter Enteral Nutr 1988;12:93-99.
ABSTRACT  

A Comparison of Intestinal Adaptation to Short-Term Intravenous Versus Intragastric Diet in Adult Rats
Raul et al.
JPEN J Parenter Enteral Nutr 1987;11:389-393.
ABSTRACT  

Carcass and Organ Composition of Rats Fed High Fat Total Parenteral Nutrition
Enrione et al.
JPEN J Parenter Enteral Nutr 1987;11:152-158.
ABSTRACT  

Rabbit Care Unit for Intravenous Feeding and Metabolic Studies
Haukipuro and Harju
JPEN J Parenter Enteral Nutr 1986;10:670-672.
ABSTRACT  

Phosphate Balance and Distribution during Total Parenteral Nutrition: Effect of Calcium and Phosphate Additives
Al-Jurf and Chapmann-Furr
JPEN J Parenter Enteral Nutr 1986;10:508-512.
ABSTRACT  

Alterations in Exogenous Substrate Metabolism in Sepsis
Fried et al.
Arch Surg 1986;121:173-178.
ABSTRACT  

Total Parenteral Nutrition in the Mouse: Body Composition and Plasma Chemistries
Sitren et al.
JPEN J Parenter Enteral Nutr 1985;9:600-604.
ABSTRACT  

Total Parenteral Nutrition with and without Fat as Substrate for Growth of Rats and Transplanted Hepatocarcinoma
King et al.
JPEN J Parenter Enteral Nutr 1985;9:422-427.
ABSTRACT  

Evaluation of the Effect of Arginine-Enriched Amino Acid Solution on Tumor Growth
Tachibana et al.
JPEN J Parenter Enteral Nutr 1985;9:428-434.
ABSTRACT  

A New Method for Long-Term Intravenous Alimentation in Unrestrained Rats
Abrahamian et al.
JPEN J Parenter Enteral Nutr 1984;8:581-584.
ABSTRACT  

Effects of Exogenous Catecholamines on Glucose and Fat Metabolism and on Triglycerides in the Rat Liver during Total Parenteral Nutrition
Iriyama et al.
JPEN J Parenter Enteral Nutr 1984;8:412-415.
ABSTRACT  

Lipid-Based Parenteral Nutrition and the Immunosuppression of Protein Malnutrition
Wagner and Silberman
Arch Surg 1984;119:809-810.
ABSTRACT  

Fat-Based (Intralipid 20%) Versus Carbohydrate-Based Total Parenteral Nutrition: Effects on Hepatic Structure and Function in Rats
Boelhouwer et al.
JPEN J Parenter Enteral Nutr 1983;7:530-533.
ABSTRACT  

Total Parenteral Nutrition in the Mouse: Development of a Technique
Sitren et al.
JPEN J Parenter Enteral Nutr 1983;7:582-586.
ABSTRACT  

Enhanced Tumor Response to Cycle-Specific Chemotherapy by Parenteral Amino Acid Administration
Torosian et al.
JPEN J Parenter Enteral Nutr 1983;7:337-345.
ABSTRACT  

Effect of Intravenous Fat Emulsion on Experimental Acute Pancreatitis
Raasch et al.
JPEN J Parenter Enteral Nutr 1983;7:254-256.
ABSTRACT  

The Effect of Intravenous Doxycycline Hyclate on Total Parenteral Nutrition in Protein Malnourished Rats
Lees et al.
JPEN J Parenter Enteral Nutr 1981;5:510-512.
ABSTRACT  

Stress Induced by Light Weight Back Button Used to Prepare the Rat for Continuous Intravenous Infusion
Birkhahn et al.
JPEN J Parenter Enteral Nutr 1979;3:421-423.
ABSTRACT  

Protein-Sparing Effect of Intravenously Administered Branched Chain Amino Acids in Adult Rats
Yoshimura et al.
JPEN J Parenter Enteral Nutr 1978;2:525-531.
ABSTRACT  

Total Parenteral Nutrition In Miniature Swine: Essential Fatty Acid Deficiency
Badger et al.
JPEN J Parenter Enteral Nutr 1978;2:116-123.
 

Selective Habitation of Bacteria on "Intermediate Soft" Keratin Surfaces of the Rat Tongue
Kaster and Cameron
JDR 1978;57:139-145.
ABSTRACT  

The genesis of intravenous hyperalimentation
Dudrick
JPEN J Parenter Enteral Nutr 1977;1:23-29.