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Effect of Isoproterenol and Lactated Ringer's Solution

Hannes B. Staehelin, MD; Leonard L. Bailey, MD; Louis L. Smith, MD

AMA Arch Surg. 1972;104(5):692-695.

Abstract
Isoproterenol hydrochloride and lactated Ringer's solution were employed in the treatment of low perfusion acidosis produced by acute blood volume reduction in 27 dogs. Their relative effectiveness was determined by measuring oxygen consumption, cardiac rate and output, and blood pressure. Neither isoproterenol nor lactated Ringer's solution produced significant improvement in either cardiac function or oxygen uptake. Significant improvement did, however, result when lactated Ringer's solution and isoproterenol were used in combination.

Author Affiliations
Loma Linda, Calif

From the Department of Surgery, Surgical Research Laboratory, Loma Linda (Calif) University School of Medicine.

Footnotes
Accepted for publication Nov 23, 1971.

Reprint requests to the Department of Surgery, Loma Linda University School of Medicine, Loma Linda, Calif 92354 (Dr. Smith).

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