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Influence of Barium Sulfate or Water-Soluble Radiographic Contrast Material on Survival

Ronald J. Sisel, MD; Arthur J. Donovan; Albert E. Yellin, MD

AMA Arch Surg. 1972;104(6):765-768.

Abstract
Experimental colonic rupture in rabbits followed by an enema of barium sulfate or water-soluble radiographic contrast media was, without treatment, uniformly fatal. Surgical repair of the colonic rupture and peritoneal lavage resulted in only 10% survival in animals with peritonitis due to feces mixed with barium. Fifty percent of animals with peritonitis due to feces mixed with water-soluble media, and in which surgical repair was performed promptly, survived. These results suggest that water-soluble contrast materials be more strongly considered for employment when a contrast enema is considered indicated during acute-phase abdominal illness.

Author Affiliations
Los Angeles

From the Department of Surgery, University of Southern California School of Medicine, Los Angeles.

Footnotes
Accepted for publication Feb 15, 1972.

Read before the annual meeting of the Southern California Chapter of the American College of Surgeons, Santa Barbara, Calif, Jan 14,1972.

Reprint requests to University of Southern California School of Medicine, 1200 N State St, Los Angeles 90033 (Dr. Yellin).

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