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Glen R. Silcott, MD; Benjamin H. Barbour, MD; Robert Mendez, MD; Margot D. Bischel, MD; Thomas V. Berne, MD

AMA Arch Surg. 1972;104(6):791-793.

Abstract
A study of 62 renal allografts was made to determine which characteristics of acute rejection may allow early identification of those grafts with a very low probability of ultimate success. Graft survival was reduced to below 20% and patient survival to below 50% with the fourth acute rejection episode. Of those grafts which were unable to return the serum creatinine value to within 20% of the prerejection level, 93% ultimately failed and 47% of the patients died. These features of acute rejection offered the best guides to the ultimate outcome of the transplant and are useful in determining when to abandon a renal allograft rather than subject the patient to the risks of additional immunosuppression.

Author Affiliations
Los Angeles

From the departments of surgery and medicine, University of Southern California School of Medicine, Los Angeles.

Footnotes
Accepted for publication Feb 15, 1972.

Read before the annual meeting of the Southern California Chapter of the American College of Surgeons, Santa Barbara, Calif, Jan 14,1972.

Reprint requests to 1200 N State St, Los Angeles 90033 (Dr. Berne).

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