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Effects of Intra-Aortic Thrombin Infusions on Renal and Mesenteric Blood Flow in the Dog

Johan Hoie, MD; Worthington G. Schenk, Jr., MD, FACS

AMA Arch Surg. 1972;104(6):838-841.

Abstract
Cardiac output and renal and superior mesenteric artery flow were measured with noncannulating electromagnetic flow probes during and after intra-aortic infusion of thrombin (75 National Health [NIH] units/ kg body weight during 30 minutes) in the dog. The infusion provoked an episode of intravascular coagulation during which 60% of the plasma fibrinogen was consumed. The cardiac output dropped 24%, renal flow decreased 73%, and mesenteric blood flow increased 6%. After the infusion stopped, this regional flow redistribution abated and the renal and mesenteric flow almost regained their initial share of cardiac output within 30 minutes. The thrombin infusion induced vasoconstriction of the renal and vasodilatation of the mesenteric vasculature limited to the period of infusion. Heparinization prevented both these reactions and the consumption of fibrinogen. The importance of thrombin released vasoactive substances in the hemodynamic response to thrombin is suggested.

Author Affiliations
Buffalo

From the Department of Surgery, State University of New York at Buffalo and the Surgical Research Laboratories, Edward J. Meyer Memorial Hospital, Buffalo.

Footnotes
Accepted for publication Dec 8, 1971.

Reprint requests to 462 Grider St, Buffalo (Dr. Schenk).

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