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Influence of Hypercalcemia on Clinical Course

Wilson J. Turbey, MD; Edward Passaro, Jr., MD

AMA Arch Surg. 1972;105(1):62-66.

Abstract
While parathyroid hyperplasia or adenoma is commonly found in patients who also have gastrin-producing tumors (Zollinger-Ellison syndrome), to our knowledge the influence of one on the other has not been previously documented.

Four patients with elevated serum gastrin levels had elevated serum calcium levels. All underwent parathyroidectomy. Three patients had a marked clinical improvement and decreased basal acid secretion after calcium levels were returned to normal. Two patients demonstrated a prompt decline in serum gastrin levels following excision of parathyroid adenomas or hyperplastic glands. The fourth patient had a previous total gastrectomy and persistently elevated serum gastrin levels. He developed hypercalcemia years later.

Author Affiliations
Los Angeles

From the Surgical Service, Veterans Administration Hospital (Wadsworth), and the Department of Surgery, UCLA School of Medicine, Los Angeles.

Footnotes
Accepted for publication Feb 18, 1972.

Read before the annual meeting of the Southern California Chapter of the American College of Surgeons, Santa Barbara, Calif, Jan 16,1972.

Reprint requests to Surgical Service, Veterans Administration Hospital (Wadsworth), Wilshire and Sawtelle boulevards, Los Angeles 90073 (Dr. Passaro).

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