This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on Web of Science (20)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Prospective Gastric Secretion Composition

John F. Stremple, MD; Mark D. Molot, MD; J. Judson McNamara, MD; Haruki Mori, MD; George B. Jerzy Glass, MD

AMA Arch Surg. 1972;105(2):177-185.

Abstract
Nine of 50 combat casualties studied prospectively developed severe gastric hemorrhage due to proved gastric ulcers. On the day of injury, gastric acid outputs were very low (30 ± 14 mEq/24 hr) in all patients, and increased thereafter. Urinary steroid excretion was always within the normal range. Total gastric juice sialic acid output was identical, whether bleeding occurred or not.

The actual total "leak" plasma protein output was significantly greater in those who developed gastric ulcers (8 gm for six days), than in those who did not have clinically significant bleeding (5 gm for six days). Initial decreased acid output, accompanied by plasma protein "leakage" into the gastric lumen, is consistent with back diffusion of H⁺ ions soon after trauma.

Author Affiliations
Pittsburgh

From the University of Pittsburgh School of Medicine (Dr. Stremple), Pittsburgh; New York Medical College (Drs. Mori and Glass), New York; and Division of Surgery, Walter Reed Institute of Research (Drs. Stremple, Molot, and McNamara), Washington, DC.

Footnotes
Accepted for publication April 7, 1972.

Read before the 29th annual meeting of the Central Surgical Association, Chicago, March 2, 1972.

Reprint requests to Department of Surgery, University of Pittsburgh School of Medicine, VA Hospital, University Drive C, Pittsburgh 15240 (Dr. Stremple).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?