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Thromboembolic Complications During Anticoagulant Therapy
William W. Coon, MD;
Park W. Willis, III, MD
AMA Arch Surg. 1972;105(2):209-212.
Abstract
Patients who developed thromboembolic complications when they received anticoagulant therapy were compared with control patients who did not develop the same symptoms, but were matched for other epidemiologic variables. The controls had more days of heparin sodium therapy and received higher doses of the drug. They also received anticoagulant treatment orally for more days while their prothrombin rates were below 30% and 25%, but these differences were not statistically significant. These data in combination with other studies, which show that anticoagulants administered orally probably reach their maximum antithrombotic effectiveness after the first week of administration, support the recommendation that every patient with thromboembolism should receive heparin therapy concurrently with anticoagulant therapy, administered orally, for at least seven to ten days.
Author Affiliations
Ann Arbor, Mich
From the departments of surgery and medicine, University of Michigan, Ann Arbor.
Footnotes
Accepted for publication April 7, 1972.
Read before the 29th annual meeting of the Central Surgical Association, Chicago, March 2, 1972.
Reprint requests to Department of Surgery, University of Michigan Medical Center, 1405 E Ann St, Ann Arbor, Mich 48104 (Dr. Coon).
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