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Hrair P. Gulesserian, MD; Richard L. Lawton, MD; Robert E. Condon, MD

AMA Arch Surg. 1972;105(2):280-285.

Abstract
Eight patients with severe symptoms due to hepatic metastases were treated by hepatic artery ligation and infusion of the distal hepatic arterial system with fluorouracil. Minor deterioration in liver function occurred, which was reversible within nine days. Serial liver scans showed reduction in size of the deposits and tumor necrosis was demonstrated in one patient on liver biopsy. All patients improved considerably in terms of symptoms and seven are still alive and in clinical remission. Significant palliative effects can be achieved by hepatic artery ligation and infusion. Morbidity and mortality are minimal.

Author Affiliations
Iowa City

From the Department of Surgery, College of Medicine, University of Iowa, Iowa City.

Footnotes
Accepted for publication April 7, 1972.

Read before the 29th annual meeting of the Central Surgical Association, Chicago, April 11, 1972.

Reprint requests to Department of Surgery, University of Iowa College of Medicine, Iowa City 52240 (Dr. Gulesserian).

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