This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citing articles on HighWire  • Citing articles on Web of Science (14)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Substrate for Ischemic Intestine

A. Hope McArdle, PhD; Chu-Jeng Chiu, MD; Fraser N. Gurd, MD

AMA Arch Surg. 1972;105(3):441-445.

Abstract
The introduction of radioactive glucose into the lumen of canine intestinal loops during superior mesenteric arterial occlusion afforded protection from the classical morphological ischemic injury. A comparison was made with loops containing iso-osmotic radioactive methylglucose, which is transported by the intestine but not metabolized. The epithelial cells utilized the luminal glucose as substrate (measured by the production of radioactive lactate). Neither metabolic utilization nor morphological protection was observed with methyl-glucose. Furthermore, the glucose-containing loop showed less fluid loss into the lumen following restoration of blood flow than when methylglucose was present. The protection with glucose was not simply an osmotic effect, since no protection was manifested with iso-osmotic methylglucose. It appears, therefore, that the utilization of glucose as substrate for the ischemic intestinal cells afforded the protection from injury.

Author Affiliations
Montreal

From the McGill University Surgical Clinic, Montreal General Hospital, Montreal.

Footnotes
Accepted for publication Jan 10, 1972.

Reprint requests to the McGill University Surgical Clinic, Montreal General Hospital, Montreal (Dr. McArdle).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Starvation, Glucose, and Stress Ulcers in the Rat
Mullane et al.
Arch Surg 1974;109:416-419.
ABSTRACT