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Robert S. Richardson; Lawrence W. Norton, MD; John E. L. Sales, FRCS; Ben Eiseman, MD

AMA Arch Surg. 1973;106(2):191-195.

Abstract
The effect of endotoxin shock on the distribution of gastric blood flow was measured with radioactive microspheres in a swine stress ulcer model. Ten piglets were shocked with intravenously administered Escherichia coli endotoxin and compared with six controls. Blood flow was calculated before and after shock by assaying 2-cm square sections of stomach. Distribution of gastric blood flow was analyzed graphically and ischemic regions were compared to ulcerated areas. Endotoxin caused a redistribution of gastric blood flow which did not parallel cardiac output change. Ischemia was maximum in the corpus where flow per gram decreased 62.2%, and stress ulcers developed only in this region in all shocked animals. There were no ulcers in controls where gastric blood flow paralleled cardiac output. Endotoxin caused a selective regional gastric ischemia unlike the diffuse, patchy flow seen following hemorrhage.

Author Affiliations
Denver

From the Department of Surgery, University of Colorado Medical Center, Denver.

Footnotes
Accepted for publication Sept 21, 1972.

Reprint requests to Department of Surgery, Denver General Hospital, W Eighth and Cherokee Streets, Denver 80204 (Dr. Eiseman).

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