This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on Web of Science (56)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Clinical Significance

Charles E. Lucas, MD; Frederick E. Rector, MD; Michael Werner, MD; Irwin K. Rosenberg, MD

AMA Arch Surg. 1973;106(4):444-449.

Abstract
Effects of sepsis on renal function were evaluated in 65 patients acutely ill with peritonitis from different causes. The indexes measured included glomerular filtration rate, effective renal plasma flow, true renal plasma flow, osmolar clearance, sodium clearance, and serum osmolar differences.

Average glomerular filtration rate and effective renal plasma flow were slightly depressed. Extraction of para-aminohippurate through the kidney was markedly decreased so that true renal blood flow was elevated in direct proportion to cardiac output. Urine volumes were usually high and many patients exhibited a syndrome of inappropriate polyuria at the expense of effective circulating plasma volume, leading to relative hypovolemia. Although average serum osmolality and osmolar difference were markedly elevated, the average osmolar clearance was within normal range. These data suggest that sepsis causes renal vasodilation. The therapeutic implications of these findings are discussed.

Author Affiliations
Detroit

From the Department of Surgery, Wayne State University School of Medicine; and the Detroit General Hospital Research Corporation, Detroit.

Footnotes
Accepted for publication Dec 15, 1972.

Read before the 80th annual meeting of the Western Surgical Association, Rochester, Minn, Nov 16, 1972.

Reprint requests to 540 E Canfield Ave, Detroit 48201 (Dr. Lucas).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Septic Acute Kidney Injury in Critically Ill Patients: Clinical Characteristics and Outcomes
Bagshaw et al.
CJASN 2007;2:431-439.
ABSTRACT | FULL TEXT  

Manifestations of Sepsis
Harris et al.
Arch Intern Med 1987;147:1895-1906.
ABSTRACT  

The Cardiopulmonary Response to Massive Doses of Steroids in Patients With Septic Shock
Lucas and Ledgerwood
Arch Surg 1984;119:537-541.
ABSTRACT  

Mechanism of Inappropriate Polyuria in Septic Patients
Cortez et al.
Arch Surg 1977;112:471-476.
ABSTRACT