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Eric W. Fonkalsrud, MD; Abdel-Khalek Sarwat, MD; Isao Higashijima, MD; Manuel Sanchez; George Chappell

AMA Arch Surg. 1973;106(6):785-787.

Abstract
To assess the influence of bilateral pulmonary hypertension on the success of lung allotransplantation, 19 dogs underwent bilateral simultaneous pulmonary artery (PA) banding. This elevated mean PA pressures from 17/6 to 41/15 mm Hg. Later left lung allotransplantation lowered mean PA pressure to 22/9 mm Hg, and blood flow measurements two weeks later showed 70% of PA flow to be through the graft. Mean survival of 36.4 days compared favorably with that of normal recipients. Slight pulmonary edema occurred in most grafted lungs and was severe enough to cause two deaths. Since in the clinical setting presence of diseased lungs may compel the graft to accept 50% or more of the blood flow, the shortest possible ischemic and nonventilation times must be arranged. Cardiopulmonary bypass was unnecessary in the presence of pulmonary hypertension 2 times normal.

Author Affiliations
Los Angeles

From the Department of Surgery, UCLA School of Medicine, Los Angeles.

Footnotes
Accepted for publication March 2, 1973.

Read before the annual meeting of the Southern California Chapter of the American College of Surgeons, Newport Beach, Calif, Jan 19, 1973.

Reprint requests to Department of Surgery, Center for Health Sciences, UCLA School of Medicine, Los Angeles 90024 (Dr. Fonkalsrud).

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