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Experience With Fat Emulsions and Hypertonic Glucose

Melvyn T. Yeo, MD; Alan B. Gazzaniga, MD; Robert H. Bartlett, MD; Judy B. Shobe, RN

AMA Arch Surg. 1973;106(6):792-796.

Abstract
Hypertonic glucose and nitrogen total intravenous nutrition (TIN) has become established treatment for certain critically ill patients. Complications with this technique have been significant and death has occurred. These complications are related to the need for prolonged maintenance of a central venous catheter and metabolism of large amounts of glucose. A soybean oil emulsion (Intralipid) has been used extensively in Europe and can provide calories through peripheral vein administration. This emulsion was given to 12 postoperative patients. There were no complications, and four of six patients studied developed positive nitrogen balance. In a similar group of four patients, glucose TIN produced weight gain and positive nitrogen balance in each case. The benefits of TIN are unchallenged, and positive nitrogen balance can be achieved in adults with either fat or glucose and a source of nitrogen.

Author Affiliations
Irvine, Calif

From the Department of Surgery, University of California, Irvine.

Footnotes
Accepted for publication March 2, 1973.

Read before the annual meeting of the Southern California Chapter of the American College of Surgeons, Newport Beach, Calif, Jan 19, 1973.

Reprint requests to Department of Surgery, University of California Medical School, Irvine, CA 92664 (Dr. Yeo).

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