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Bilateral Nephrectomy and Renal Homotransplantation for Malignant Nephrosclerosis
John E. Payne, MB, BS, FRCS (Ed);
Glenn R. Silcott, MD;
Robert Mendez, MD;
Benjamin H. Barbour, MD;
Thomas V. Berne, MD
AMA Arch Surg. 1973;107(1):17-20.
Abstract
The effects of hemodialysis, bilateral nephrectomy, and renal homotransplantation were evaluated in 12 patients with renal failure due to primary malignant hypertension. The blood pressure was difficult to control with hemodialysis, moderately high doses of antihypertensives, and dietary restriction. Bilateral nephrectomy resulted in significant reduction of diastolic blood pressure and reduction in the number and quantities of antihypertensive medication. Fourteen renal homografts were performed. Patient survival and transplant function compare favorably with other patients transplanted by us and those reported to the Human Transplant Registry. In the posttransplant period, hypertension was a problem in only two patients. The mean diastolic blood pressure was similar to that achieved by bilateral nephrectomy. Renal transplantation is an acceptable therapy for patients who have been treated by bilateral nephrectomy for malignant nephrosclerosis.
Author Affiliations
Los Angeles
From the departments of medicine and surgery, Los Angeles County-University of Southern California Medical Center.
Footnotes
Accepted for publication March 2, 1973.
Read before the annual meeting of the Southern California Chapter of the American College of Surgeons, Newport Beach, Calif, Jan 20, 1973.
Reprint requests to Department of Surgery, Los Angeles County-University of Southern California Medical Center, 1200 N State St, Los Angeles 90033 (Dr. Payne).
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ABSTRACT
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