This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Effect of Major Acute Hemorrhage and of Crystalloid Infusion in the Dog

Stanley Z. Cowen, MD; Edward J. White, MD; Arthur J. Donovan, MD

AMA Arch Surg. 1973;107(1):56-61.

Abstract
The early effect on the arterial hematocrit reading of major acute arterial hemorrhage and of crystalloid infusion has been studied in splenectomized dogs. Within 30 minutes of completion of hemorrhage of 25% of estimated blood volume, the arterial hematocrit reading had decreased 15% from base line and remained at that level for the ensuing five hours. This rapid rate of transcapillary refill was comparable whether the hemorrhage was external or "intraperitoneal." The infusion of 0.9% sodium chloride solution in a volume equal to 75% of estimated blood volume over two hours resulted in a decrease in hematocrit reading during the infusion exceeding the decrease to be anticipated if the entire infused solution were equally distributed throughout the extracellular space. This apparent delayed dispersal of crystalloid from the intravascular to the interstitial space was not modified by prior hemorrhage.

Author Affiliations
Los Angeles

From the Department of Surgery, University of Southern California School of Medicine, and Los Angeles County-University of Southern California Medical Center. Dr. Donovan is now with the University of South Alabama, Mobile, Ala.

Footnotes
Accepted for publication March 8, 1973.

Read before the annual meeting of the Southern California Chapter of the American College of Surgeons, Newport Beach, Calif, Jan 19, 1973.

Reprint requests to University of South Alabama, 307 Gaillard Dr, Mobile, AL 36608 (Dr. Donovan).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?