This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citing articles on HighWire  • Citing articles on Web of Science (49)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

A Comparison

James M. Blackwood, MD; John Hsieh; John Fewel; Benjamin F. Rush, Jr., MD

AMA Arch Surg. 1973;107(2):181-185.

Abstract
Tissue levels of adenosine triphosphate (ATP), lactic acid, and glucose were measured in previously splenectomized mongrel dogs subjected to hemorrhagic shock or to endotoxin shock. In the 13 hemorrhagic shock dogs, mean liver ATP dropped by 75% and small bowel ATP by 50%. There was little change in the corresponding mean ATP levels in the eight endotoxin shock dogs (P =.01 to.02). Lactic acid was higher in all tissues in the hemorrhagic group, significantly so in muscle and liver (P =.01 to .02). Glucose/glycogen in muscle and liver decreased to comparable levels in both groups. These findings suggest that anaerobic metabolism in tissues is a more important component of hemorrhagic shock than it is of endotoxin shock.

Author Affiliations
Newark, NJ

From the College of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark.

Footnotes
Accepted for publication March 30, 1973.

Read before the 30th annual meeting of the Central Surgical Association, Toronto, Feb 22, 1973.

Reprint requests to Martland Hospital, Department of Surgery, 65 Bergen St, Newark, NJ 07107 (Dr. Blackwood).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Effect of Injury, Sepsis, and Parenteral Nutrition on High-Energy Phosphates in Human Liver and Muscle
Liaw
JPEN J Parenter Enteral Nutr 1985;9:28-33.
ABSTRACT  

Myocardial Adenosine Triphosphate Levels During Early Sepsis
Pasque et al.
Arch Surg 1983;118:1437-1440.
ABSTRACT