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Instances in Dogs With Specific Enhancing Immunoglobulin and Its Proteolytic Fragments

Robert H. Yonemoto, MD; Robert M. Deliman, MD; William D. DuSold, MD; Thomas Hamilton

AMA Arch Surg. 1973;107(3):390-394.

Abstract
Dog-specific IgG and Fab was produced from dogs immunized against donor dog's spleen and kidney. Goat antidog kidney F(ab')₂ was secured by immunizing goats against donor dog's kidney. These specific enhancing immunoglobulin and proteolytic fragments were perfused intrarenally via the renal artery following the renal allograft made in the neck. Dogs treated with IgG survived on the average of 9.9 days, whereas the mean survival time of five dogs treated with Fab was 5.6 days, excluding one longterm survivor of 31 days. Dogs receiving goat F(ab')₂ had a mean survival time of 11.0 days, which was not statistically significant when compared with control dogs with MST of 8.7 days. Although F(ab')₂ has been successfully utilized to prolong renal allografts in other experimental models, we have not been able to achieve enhancement in our canine model system.

Author Affiliations
Duarte, Calif

From the Department of General and Oncologic Surgery, City of Hope National Medical Center, Duarte, Calif.

Footnotes
Accepted for publication May 2, 1973.

Read before the annual meeting of the Southern California Chapter of the American College of Surgeons, Newport Beach, Calif, Jan 19, 1973. Reprint requests to 1500 E Duarte Rd, Duarte, Calif 91010 (Dr. Yonemoto).

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