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I. The Action of Bile

Herbert Schapiro, PhD; Louis G. Britt, MD; Carolyn F. Blackwell, MD; Kenneth J. Gaines, MD

AMA Arch Surg. 1973;107(4):608-612.

Abstract
Acute hemorrhagic pancreatitis was produced in the dog by the closed-loop technique. The presence of bile in the closed loop was not needed to induce the pancreatitis; however, its presence influenced the appearance of the disease. Bile in the closed loop caused an earlier appearance of pancreatic acinar tissue disruption and elevated serum lipase, alkaline phosphatase, and lactic dehydrogenase levels; there were increased fluid volumes in the closed loop and higher amylase concentrations in the peritoneal fluid.

Author Affiliations
From the departments of anatomy and surgery, University of Tennessee Medical Units, Memphis V. A. Hospital; and the Department of Pathology, Baptist Memorial Hospital, Memphis.

Footnotes
Accepted for publication March 6, 1973.

Reprint requests to Department of Anatomy, Eastern Virginia Medical School, 358 Mowbray Arch, Norfolk, VA 23507 (Dr. Schapiro).

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