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Corticosteroid Treatment of Major TraumaMechanisms Involved in Their Therapeutic Effect
Peter Woodruff, MB, FRCS (Edin);
Dimitri Caridis, MD, FRCS (Edin);
Peter Cuevas, MD;
Sumihiko Koizumi, MD;
Jacob Fine, MD
AMA Arch Surg. 1973;107(4):613-616.
Abstract
Corticosteroids injected into the upper abdominal aorta of rabbits, accelerated the clearance rate of endotoxin injected into the circulation, and of endotoxin that had entered the circulation from the intestine following an ischemic injury to the intestine. They also prevented or eliminated the endotoxemia of intestinal origin produced by a 30% immersion burn. Preliminary data suggest that they facilitate faster clearance by preventing the excessive release of norepinephrine by endotoxin.
Author Affiliations
Boston
From the Harvard Surgical Unit, Boston City Hospital.
Footnotes
Accepted for publication March 13, 1973.
Reprint requests to Harvard Surgical Unit, Boston City Hospital, Boston 02118 (Dr. Fine).
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ABSTRACT
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