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  Vol. 107 No. 4, October 1973 TABLE OF CONTENTS
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Corticosteroid Treatment of Major Trauma

Mechanisms Involved in Their Therapeutic Effect

Peter Woodruff, MB, FRCS (Edin); Dimitri Caridis, MD, FRCS (Edin); Peter Cuevas, MD; Sumihiko Koizumi, MD; Jacob Fine, MD

AMA Arch Surg. 1973;107(4):613-616.


Abstract



Corticosteroids injected into the upper abdominal aorta of rabbits, accelerated the clearance rate of endotoxin injected into the circulation, and of endotoxin that had entered the circulation from the intestine following an ischemic injury to the intestine. They also prevented or eliminated the endotoxemia of intestinal origin produced by a 30% immersion burn. Preliminary data suggest that they facilitate faster clearance by preventing the excessive release of norepinephrine by endotoxin.



Author Affiliations



Boston

From the Harvard Surgical Unit, Boston City Hospital.


Footnotes



Accepted for publication March 13, 1973.

Reprint requests to Harvard Surgical Unit, Boston City Hospital, Boston 02118 (Dr. Fine).



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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Glucocorticoid and Antibiotic Effect on Experimental Gram-Negative Bacteremic Shock
Pitcairn et al.
Arch Surg 1975;110:1012-1015.
ABSTRACT  





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