This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Mechanisms Involved in Their Therapeutic Effect

Peter Woodruff, MB, FRCS (Edin); Dimitri Caridis, MD, FRCS (Edin); Peter Cuevas, MD; Sumihiko Koizumi, MD; Jacob Fine, MD

AMA Arch Surg. 1973;107(4):613-616.

Abstract
Corticosteroids injected into the upper abdominal aorta of rabbits, accelerated the clearance rate of endotoxin injected into the circulation, and of endotoxin that had entered the circulation from the intestine following an ischemic injury to the intestine. They also prevented or eliminated the endotoxemia of intestinal origin produced by a 30% immersion burn. Preliminary data suggest that they facilitate faster clearance by preventing the excessive release of norepinephrine by endotoxin.

Author Affiliations
Boston

From the Harvard Surgical Unit, Boston City Hospital.

Footnotes
Accepted for publication March 13, 1973.

Reprint requests to Harvard Surgical Unit, Boston City Hospital, Boston 02118 (Dr. Fine).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Glucocorticoid and Antibiotic Effect on Experimental Gram-Negative Bacteremic Shock
Pitcairn et al.
Arch Surg 1975;110:1012-1015.
ABSTRACT