This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citing articles on HighWire  • Citing articles on Web of Science (9)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Madhira D. Ram, MD; Sukawat Watanatittan, MD

AMA Arch Surg. 1974;108(2):187-189.

Abstract
Cephalothin sodium levels in serum, gallbladder bile, gallbladder tissue, and common duct bile were studied in both normal patients and patients with biliary disease. The results show that cephalothin is concentrated in bile in normal patients and patients with gallbladder disease. In the presence of jaundice, results are less conclusive. Following a single dose of the drug, peak level in bile was reached at two hours; the level at eight hours was less than 1µg/ml in patients with biliary drainage through a T tube in the common bile duct.

Since the antibacterial spectrum of cephalothin includes a large number of common biliary pathogens, and since the concentration of the drug in bile reaches levels higher than the minimal inhibitory and even bactericidal concentration in the absence of obstructive jaundice, it could be of value in the treatment of biliary infections.

Author Affiliations
Cleveland

From the Department of Surgery, Huron Road Hospital, Cleveland.

Footnotes
Accepted for publication Sept 11, 1973.

Reprint requests to Department of Surgery, Huron Road Hospital, Cleveland 44112 (Dr. Ram).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Cholestatic Jaundice in Adults: Algorithms for Diagnosis
Fischer et al.
JAMA 1981;245:1945-1948.
ABSTRACT