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Irshad H. Chaudry, PhD; Mohammed M. Sayeed, PhD; Arthur E. Baue, MD

AMA Arch Surg. 1974;108(2):208-211.

Abstract
Hemorrhagic shock was produced in conscious rats by bleeding the animals to a mean arterial pressure of 40 mm Hg that was maintained for 1 hours. At the end of the shock period, the animals received (1) blood alone; or (2) blood plus Ringer lactate; or (3) adenosine triphosphate-magnesium chloride (ATP-MgCl₂) followed by blood; or (4) adenosine diphosphate-MgCl₂ (ADP-MgCl₂), or adenosine phosphate-MgCl₂ (AP-MgCl₂), or adenosine-MgCl₂ followed by blood and were killed three minutes afterward. Analysis of liver and kidney showed that ATP levels decreased during shock, and they remained low when blood, blood plus Ringer lactate or ADP-MgCl₂, AP-MgCl₂, or adenosine-MgCl₂ were given. Adenosine triphosphate levels returned to normal in both tissues only when ATP-MgCl₂ and blood were given. The effect of ATP-MgCl₂ in restoring ATP levels of liver and kidney may be through provision of the high-energy phosphate compound.

Author Affiliations
St. Louis

From the Division of Cell Physiology and the Department of Surgery, Washington University School of Medicine; and The Jewish Hospital of St. Louis (Drs. Chaudry, Sayeed, and Baue).

Footnotes
Accepted for publication Sept 11, 1973.

Read in part before the 59th Annual Clinical Congress of the American College of Surgeons, Chicago, Oct 16, 1973.

Reprint requests to 216 S Kingshighway, St Louis 63110 (Dr. Baue).

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