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An Experimental Study in a Canine Model

Werner Weissenhofer, MD; Worthington G. Schenk, Jr.

AMA Arch Surg. 1974;108(5):712-714.

Abstract
A canine hind-limb exercise model is described that permits study of pressure and flow changes through an area of arterial stenosis before, during, and after exercise.

Following creation of a critical stenosis in the external iliac artery (50% reduction in flow), exercise alone resulted in an increase in flow over the stenosis related to the degree of exercise produced, accompanied by a widening of the arteriovenous oxygen difference and an increase in oxygen consumption.

Infusion of an intra-arterial vasodilator (tolazoline hydrochloride) during the exercise period resulted in only a negligible change in flow over the stenosis, but a marked narrowing of the arteriovenous difference (30%) with a resulting reduction in limb oxygen consumption.

These findings suggest that this intraarterial vasodilator opens arteriovenous shunts, apparently bypassing the capillary bed.

Author Affiliations
Buffalo

From the Department of Surgery, State University of New York at Buffalo, and the Surgical Research Laboratories, Edward J. Meyer Memorial Hospital, Buffalo.

Footnotes
Accepted for publication Dec 4, 1973.

Reprint requests to Department of Surgery, State University of New York at Buffalo, 462 Grider St, Buffalo, NY 14215 (Dr. Schenk).

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