This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

II. Surgical Application of Tissue Culture Expanded Rabbit-Skin Autografts

Howard J. Igel, MD; Aaron E. Freeman, PhD; Clifford R. Boeckman, MD; Karen L. Kleinfeld, MT

AMA Arch Surg. 1974;108(5):724-729.

Abstract
The coverage of large surface area skin wounds with autograft skin is limited by the amount of available viable donor-site skin. A small amount of donor-site epithelium can be expanded many times over by cultivation in tissue culture on sheets of skin allografts or xenografts. Experiments performed in rabbits indicate that such autograft-allografts or autograft-xenografts can be transplanted to large surface area wounds with essentially complete epithelial coverage of the wounds within two to three weeks, even with wound surface area coverage 50 times the surface area of donor-site skin.

Author Affiliations
Akron, Ohio

From the Children's Hospital, Akron, Ohio.

Footnotes
Accepted for publication Nov 21, 1973.

Reprint requests to Children's Hospital, Buchtel Ave at Bowery St, Akron, OH 44308 (Dr. Igel).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Cultured Skin Grafts: Past, Present, Future
Phillips
Arch Dermatol 1988;124:1035-1038.
ABSTRACT  

Porous Collagen Sponge Wound Dressings: in vivo and in vitro Studies
Doillon
J Biomater Appl 1987;2:562-578.
ABSTRACT