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Sclerosis of the Extrahepatic Bile Ducts
James J. Peck, MD;
William H. Kern, MD;
William P. Mikkelsen, MD
AMA Arch Surg. 1974;108(6):798-800.
Abstract
This is a retrospective study of 13 patients with sclerosis of the common bile duct seen over a ten-year period at the Hospital of the Good Samaritan Medical Center. Histologic examination of the common bile duct in eight patients permitted a clear-cut diagnosis of sclerosing carcinoma. In the remaining five patients, glandular atypia and sclerosis were suggestive, but not diagnostic, of carcinoma. Three of these were eventually established as carcinoma at autopsy. The diagnosis in the last two patients, who are still alive, remains equivocal. This study emphasizes the difficulty of separating benign from malignant disease of the common bile duct and suggests that the majority of patients diagnosed as having primary sclerosing cholangitis will eventually be proved to have carcinoma. It further identifies the protracted course that some of these patients exhibit.
Author Affiliations
Los Angeles
From the departments of surgery (Drs. Peck and Mikkelsen) and pathology (Dr. Kern), Hospital of the Good Samaritan Medical Center, Los Angeles.
Footnotes
Accepted for publication Feb 13, 1974.
Read before the annual meeting of the Southern California Chapter of the American College of Surgeons, Palm Springs, Calif, Jan 20, 1974.
Reprint requests to Department of Surgery, Hospital of the Good Samaritan Medical Center, 1212 Shatto St, Los Angeles, CA 90017 (Dr. Mikkelsen).
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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
Primary Sclerosing Cholangitis
Oviedo et al.
Arch Surg 1974;109:747-749.
ABSTRACT
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