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Roy L. Chapman, Jr., MD; John B. Downs, MD; Jerome H. Modell, MD; C. Ian Hood, MB, ChB

AMA Arch Surg. 1974;108(6):858-861.

Abstract
Following aspiration of 0.1N hydrochloric acid with pH 1.0, 20 mongrel dogs were ventilated mechanically for four hours. Positive end-expiratory pressure of 10 cm H₂O was added continuous positive-pressure ventilation (CPPV). In addition to CPPV, ten of the dogs received methylprednisolone (30 mg/kg body weight). The CPPV improved arterial oxygen tension, decreased venous admixture, increased arterial-venous oxygen content difference, and decreased systemic blood pressure. The addition of methyl-prednisolone did not significantly improve oxygenation, survival, or any other variable measured.

Author Affiliations
Gainesville, Fla

From the departments of anesthesiology (Drs. Chapman, Downs, and Modell) and pathology (Dr. Hood), University of Florida College of Medicine, J. Hillis Miller Health Center, and the Veterans Administration Hospital, Gainesville, Fla.

Footnotes
Accepted for publication Dec 12, 1973.

Read before the annual meeting of the American Society of Anesthesiologists, San Francisco, Oct 10, 1973.

Reprint requests to Department of Anesthesiology, Box 721, University of Florida College of Medicine, J. Hillis Miller Health Center, Gainesville, FL 32610 (Dr. Chapman).

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