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A Prospective Study

Erich W. Pollak, MD; Milo M. Webber, MD; Wiley F. Barker, MD; Winona Victery, MS; Michael Cragin; Ewa Witt

AMA Arch Surg. 1974;109(1):48-51.

Abstract
The ¹²⁵ I-fibrinogen uptake test (FUT) was evaluated in a series of 42 subjects to determine its ability to detect active venous thrombosis. Included were patients with recent active thrombosis, patients with long-standing quiescent venous obstruction, and normal controls.

In serial tests, increasing isotope uptake was found to occur only in patients with active thrombophlebitis (P<.01). Consequently, this criterion can serve as an index of active thrombophlebitis.

Five patients with known calf vein thrombosis had increasing FUT results at the upper thigh. Phlebography or technetium scans confirmed propagation of the thrombosis. These results suggest a screening value for the FUT in suspected propagating thrombosis. If results are confirmed by subsequent phlebography, major therapeutic changes such as intensification of anticoagulation or venous interruptions can hopefully be made before potentially lethal pulmonary embolism occurs.

Author Affiliations
Los Angeles

From the departments of surgery (Drs. Pollak and Barker) and radiological sciences (Dr. Webber) and the Laboratory of Nuclear Medicine and Radiation Biology, UCLA School of Medicine, Los Angeles.

Footnotes
Accepted for publication March 5, 1974.

Read before the annual meeting of the Southern California Chapter of the American College of Surgeons, Palm Springs, Calif, Jan 18, 1974.

Reprint requests to 2542 Westwood Blvd, Los Angeles, CA 90064 (Dr. Pollak).

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