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Autogenous Vein Grafts in Experimental Canine AtherosclerosisTheir Fate in the Abdominal Aorta and Peripheral Arteries
Henry Haimovici, MD;
Nelicia Maier, MD, PhD
AMA Arch Surg. 1974;109(1):95-102.
Abstract
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The fate of autogenous vein grafts inserted into the abdominal aorta and peripheral arteries was studied in experimentally induced canine atherosclerosis. The grafts in the abdominal aorta developed atherosclerotic changes, became dilated, and, in most instances, were surrounded by a moderate to severe fibrous reaction. Microscopically, all three coats of the vein were involved in variable degrees with characteristic morphologic and lipid degenerative changes. The grafts implanted by end-to-side anastomosis into peripheral arteries (femoral, carotid) displayed minimal or no atheromatous changes while those implanted by end-to-end anastomosis become stenosed or occluded by organized thrombi. Among the factors that may contribute to venous atherogenesis are the morphologic changes, turbulence, increased pressure, and filtration factors. When veins are placed artificially in the arterial tree, other factors than the tissue itself appear responsible for the morphologic and lipid degenerative changes.
Author Affiliations
Bronx, NY
From the Vascular Research Laboratory, Surgical Department, Montefiore Hospital and Medical Center (Drs. Haimovici and Maier), and Albert Einstein College of Medicine (Dr. Haimovici), Bronx, NY.
Footnotes
Accepted for publication Jan 2, 1974.
Reprint requests to 862 Park Ave, New York, NY 10021 (Dr. Haimovici).
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ABSTRACT
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